Chen Wei




Academic Areas: Advanced Optical Microscopy, Computational Optical Imaging, Neurophotonics, and Optical biomedical instrumentation.


Prof. CHEN Wei received both his B.S. and M.S. in Optics from Huazhong University of Science & Technology (HUST) in 2010 and 2012, respectively. He received his Ph.D. in Biomedical Engineering from Stony Brook University, New York, in 2018. He worked as a postdoctoral fellow at the Janella Research Campus (HHMI) for 6 months before moving to UC Berkeley to continue his postdoctoral training under the supervision of Prof. Na Ji from 2018 to 2023. In 2023, he returned to HUST to join the School of Mechanical Science and Engineering as a Professor.

Dr. Chen is a member of Optica and SPIE. He served as the session chair of SPIE Photonics West BIOS 2021 and as a reviewer for prestigious journals such as “Nature Photonics”, “Nature Communications”, "Optica," "Engineering," and others. Dr. Chen has received several internationally and nationally respected awards, including the Sculpted Light in the Brain Travel Award and the first prize in the National College Student Optoelectronic Design Competition. Dr. Chen is the principal investigator for national-level projects, including the National Natural Science Fund for Excellent Yong Scientists Fund Program (Overseas), and has participated in key research and development projects for the U.S. "Brain Initiative." He has also published multiple high-quality papers in top-tier journals such as "Nature Methods”, “Nature Neuroscience", "Nature Communications," "Cell Metabolism," "Molecular Psychiatry," and "eLife," and holds one U.S. patent.


Academic Degrees

09/2006-07/2010 Huazhong University of Science and Technology, Wuhan, China B.S.

09/2010-07/2012 Huazhong University of Science and Technology, Wuhan, China M.S.

08/2012-03/2018 Stony Brook University, New York, U.S. Ph.D.

Professional Experience

03/2018-08/2023 Postdoc Fellow, UC Berkeley, Berkeley, California, U.S.

03/2018-09/2018 Visiting Scientist, Janella Research Campus, Ashburn, Virginia, U.S.

08/2023-present Professor, Huazhong University of Science and Technology, Wuhan, China

Selected Publications

[1] Wei Chen, Xinxin Ge, Qinrong Zhang, Ryan Natan, Jianglan Fang, Massimo Scanziani, Na Ji, “High-throughput volumetric mapping of synaptic transmission”, Nature Methods (in press), 2024

[2] Wei Chen, Ryan Natan, Yuhan Yang, Shih-Wei Chou, Qinrong Zhang, and Ehud Isacoff, Na Ji, “In vivo volumetric imaging of calcium and glutamate activity at synapses with high spatiotemporal resolution”, Nature Communications, 2021 

[3] Chenyan Ma, Bing Li, Daniel Silverman, Xinlu Ding, Anan Li, Chi Xiao, Ganghua Huang, Kurtresha Worden, Sandra Muroy, Wei Chen, Zhengchao Xu, Chak Foon Tso, Yixuan Huang, Yufan Zhang, Qingming Luo, Kaoru Saijo, Yang Dan, “Microglia regulate sleep through calcium-dependent modulation of norepinephrine transmission”, Nature Neuroscience, 2024

[4] Rika Ohkubo*, Chih Ling Wang*, Wei-Chieh Mu*, Wei Chen, Jiang Lan Fan, Zehan Song, Andrew Widjaja, Peter Sudmant, Angela Pisco, Dena Dubal, Na Ji, Danica Chen, “The Mitochondrial Protein Folding Stress Regulates Cognitive Aging”, Cell Metabolism, 2023

[5] Qinrong Zhang*, Yuhan Yang*, Kevin Cao, Wei Chen, Santosh Paidi, Chun-Hong Xia, Richard H. Kramer, Xiaohua Gong, Na Ji, “Retinal microvascular and neuronal pathologies probed in vivo by adaptive optical twophoton fluorescence microscopy”, eLife, 2023 

[6] Yuhan Yang, Wei Chen, Jianglai Fang, Na Ji, “Adaptive optics enables aberration-free remote focusing for two-photon fluorescence microscopy”, Biomedical Optical Express, 12 (1), 354-366, 2021 

[7] Wei Chen, K. Park, Nora D. Volkow, Yingtian Pan, Alan P. Koretsky, Congwu Du, “Interactions between task-evoked cortical activity and spontaneous slow oscillations measured with neuronal calcium”, NeuroImage, 210, 116554,2020

[8] Wei Chen, Nora D Volkow, James Li, Yingtian Pan, Congwu Du, “Cocaine Decreases Spontaneous Neuronal Activity and Increases Low-Frequency Neuronal and Hemodynamic Cortical Oscillations”, Cerebral Cortex, 29 (4), 1594-1606,2018.

[9] Wei Chen, Congwu Du, Yingtian Pan, “Cerebral capillary flow imaging by wavelength-divisionmultiplexing swept-source optical Doppler tomography”, Journal of Biophotonics, 11 (8), 2018. 

[10] Xiaochun Gu, Wei Chen, Nora Volkow, Alan Koretsky, Congwu Du, Yingtian Pan, “Synchronized Astrocytic Ca2+ Responses in Neurovascular Coupling during Somatosensory Stimulation and for the Resting State”, Cell Reports, 23 (13), 3878-3890,2018. 

[11] Xiaochun Gu, Wei Chen, Jiang You, Alan P Koretsky, ND Volkow, Yingtian Pan, Congwu Du, “Longterm optical imaging of neurovascular coupling in mouse cortex using GCaMP6f and intrinsic hemodynamic signals”, NeuroImage, 165, 251-264, 2018.  

[12] Kicheon Park, Wei Chen, Nora D. Volkow, Craig P. Allen, Yingtian Pan, Congwu Du, “Hemodynamic and Neuronal Responses to Cocaine Differ in Awake versus Anesthetized Animals: Optical Brain Imaging Study”, NeuroImage, 188, 188-197, 2018. 

[13] Wei Chen*, Peng Liu*, Nora Volkow, Yingtian Pan, and Congwu Du, "Cocaine attenuates blood flow but not neuronal responses to stimulation while preserving neurovascular coupling for resting brain activity," Molecular Psychiatry, 21 (10), 1408-1416, 2016. 

[14] Wei Chen, Kicheon Park, Nora Volkow, Yingtian Pan, and Congwu Du, "Cocaine Induced Abnormal Cerebral Hemodynamic Responses to Forepaw Stimulation Assessed by Integrated Multi-wavelength Spectroimaging and Laser Speckle Contrast Imaging," IEEE Journal of Selected Topics in Quantum Electronics, 22(4):6802608, 2016. 


[1] Yingtian Pan, Wei Chen, Congwu Du, Wavelength-division-multiplexing swept-source optical doppler tomography, U. S. Patent: US20210196126A1.


Awards and Honors

2022 Travel Awards, Sculpted Light in the Brain

2010 Sci. &Tech. Achievements Award of College Students

2009 The First Prize of Optoelectronics Design for National College Students

Courses Taught